Chitosan is used in various drug delivery approaches as a pharmaceutical excipient.\nAlthough its potential as an immunomodulatory agent has been reported, its use in this capacity has\nnot been fully explored. The efficacy of chitosan as an active pharmacological agent, particularly\nin anti-inflammatory therapy in inflammatory bowel diseases (IBD), was investigated in this study.\nThe potential impact of the molecular weight (MW) and degree of deacetylation (DD) of chitosan\nwas investigated together with 5-amino salicylic acid (5-ASA) for its efficacy in a combination\nanti-inflammatory therapy in murine experimental colitis. Such a combination would potentially\nbe developed into novel dual strategies whereby chitosan acts as a mucoadhesive excipient as\nwell as provide an additional anti-inflammatory benefit........................
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